5% are TETRAPLOIDY: four sets of chromosomes
This does not mean there is anything abnormal
with the parents' genes, it merely shows that
not all eggs and sperm are equal.
There could be a number of reasons
for a single miscarriage
but when the miscarriages are recurring
they are categorized as follows:
Genetic, hormonal and anatomic.
GENETIC:
One of the parents may be a symptomless carrier
of a chromosomal abnormality.
So the parents will want to
undergo genetic counseling.
DEFINITIONS:
aneuploidy = any difference in the number of chromosomes
haploid = single set of chromosomes (23)
triploidy = three sets of chromosomes (69)
tetraploidy = four sets of chromosomes (92)
dispermy = two sperm enter egg
Triploidy is probably most frequently due to dispermy!
Tetraploidy occurs with zygotes first cell division
after chromosome duplication.
If the genetic testing shows a fetus with aneuploidy
prenatal diagnosis should be considered
because of the risk of recurrent aneuploidy
CHROMOSOMES:
Chromosomes come in pairs, twenty-three in all.
The twenty-third pair determines the sex:
Women have two X-shaped chromosomes
Men have one X and one Y shaped chromosome.
At fertilization,
the female egg keeps one of it's X chromosomes.
Whereas sperm while forming in the testicles
gets either the X or Y shaped chromosome.
The joining of an X sperm with the egg creates a female
The joining of an Y sperm with the egg creates a male
When the sperm fuses with the egg at fertilization,
the two sets of chromosomes pair up to give the
resulting fused cell forty-six chromosomes.
Each time the cell divides new cells are formed,
every one containing the full complement
of forty-six chromosomes
On the chromosome strands of the fertilized egg
are coils of DNA (deoxyribonucleic aid)
arranged into units called genes.
Encoded on genes are the blueprint for human traits:
Hair & eye color etc.
Momma Kath, ?? about chromosome abnormalities (m)
Posted By: LTB 37, m/c 10/02 and 5/03
Monday, 16 June 2003, at 05:06 PM
My OB just called with the results of the genetic testing done following my last D&C. I don't know how to take the news. He said the tests found that the fetus had a chromosome abnormality called triploidy. It had 69 chromosomes instead of 46. We didn't have the first loss tested, but does this mean that either dh or I have a chromosome abnormality?
I'm just so worried that we won't be able to have a baby now. I know I have to stay positive, but I can't help but think that there's something wrong with one of us. And I know there is nothing to be done about a person's genetic make up. Does anyone know anything about this? I've looked it up on the internet, but there's not much information. Help!!!
Thank you for sending me into the world of chromosomes, what an exciting and wonderful world the cell, DNA and chromosomes are....anyway
Triploidy = three sets of chromosomes (69)
and guess what the cause of this anomaly is....
two sperm penetrating the egg.
Seems your hubby has some aggressive guys there.
I like the sound of that because it seems fixable!
You have inspired me to work on a new page for this site.
I already have one for miscarriage
but the new one will address the issue of recurrent miscarriage
and what that could possibly mean.
I hope this finds being kind to yourself and DH as your wounds must feel very raw.
I'm sending you lots of love and positive thoughts for the future!
Momma Kath
Ladies, please send an email
with suggestions for url/links and/or books (suggested reading) to post on this page.
Momma Kath ~
I don't know if this will help anyone
but it helps me to talk about it. DH and
I tried for 2 years to get PG.
[The doctor's kept telling me it was because of my weight
but I couldn't understand that because I knew people
who were way heavier than me who got PG with
o problem and people who were skinny who couldn't get PG.
Anyway my cycles weren't normal and they found out
I had hypothyroidism so we got that regulated.
till I wasn't PG so I got scared and thought that something was
wrong with my tubes because I was not careful as a teen
and had several STDs. I went in for that test and everything
was fine no scaring or blockage at all. I knew it was a miracle.
DH had a sperm count done the first one was borderline
and the second was great. My cycles were still irregular and I wasn't PG.
I had gastric bypass surgery done in February of 2003.
The doctor told me to wait for 2 years before I got PG after the surgery.
Well in March I got PG we weren't tr! ying and honeslty didn't think
we could get PG with no AF I had lost about 30lbs but other than that nothing.
Well I tested in April and it was +. We were so excited and I did some research
on the internet and found out that lots of women have healthy babies
soon after the surgery and I had hope everything would be fine.
At 6 and 1/2 weeks I lost the baby and my world crashed around me.
They said it was a chromosome problem and that it is normal.
I deal with guilt everyday of my life. I have had people tell me
that I did this to myself or that I couldn't have handled the baby anyway.
I quit going to church because of those comments.
Then my father-in-law passed away. When we got back into town
from the funeral my pastor called and preceeded to tell me how
I killed my own baby. You knew what the doctor said and you went
ahead and got PG anyway! I went and am going through such a variety of emotions.
I get depressed, angry, and hurt to name a few. I deal with g! uilt everyday
of my life and ask myself did I kill my own baby did I b ring this on myself?
People's words hurt and we all have enough to deal with without them
saying stuff like that. I don't have any answers to any questions
I know we have all asked and if I did I would shout them from every
roof top in America. People try to give me answers but I don't like any of them.
People try to reason away why this happens and I don't think there is an answer.
I grew up learning that children are a gift from God so why would God
give us a gift and turn around and take it away. I was always taught
God heals so why didn't he heal my baby and the countless others that
have passed away. Why would God allow this to happen to us?
He can stop anything and fix everything. I have wondered why people
who hurt their children or yell at their children or hurt other people's children
get to have healthy kids and we suffer it just doesn't seem fair to me and
I don't think anyone has the answer or at least one that will satisfy me.
There are days I feel fin! e and days I don't want to get out of bed.
I wouldn't have chosen to get PG when I did and if I could do it over I would.
If I could change this for all of us I would. It has been 3 months
since my David passed on and it feels like yesterday
sometimes I wonder if it will ever get better or even fade a little.
Will the comments ever stop? I even blamed my husband because
he has a 12 year old child from a past girlfriend. I feel like the one time
I REALLY needed my prayers answered God wasn't there for me
he let me down. I want all of you to know whatever your feeling
it is okay to feel that way. People tell me I can' tbe mad at God
I need to get over it and move on. God knows how we feel
anyway so why hide it from Him. I wish I could tell everyone
what it will be like in a year or 2 but I don't know all I know is you will
get through this but you will never get over it. We are trying again
and we get our hopes up just to get them crushed again.
I wouldn't be try! ing again if I hadn't gotten PG in the first place
so we will see what happens in the next few months.
I wish the best for you all and as many of us have said no one
should have to go through this! Kristi W. 1 baby in heaven 5/1/03
God Bless
Kristi
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